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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSEN1 All Species: 14.55
Human Site: T281 Identified Species: 24.62
UniProt: P49768 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49768 NP_000012.1 467 52668 T281 T A Q E R N E T L F P A L I Y
Chimpanzee Pan troglodytes XP_001149972 443 50485 L271 P K G P L R M L V E T A Q E R
Rhesus Macaque Macaca mulatta XP_001088524 384 43068 L212 Y S S T M V W L V N M A E G D
Dog Lupus familis XP_547503 717 78133 L496 H W K G P L V L Q Q A Y L I M
Cat Felis silvestris
Mouse Mus musculus P49769 467 52621 T281 T A Q E R N E T L F P A L I Y
Rat Rattus norvegicus P97887 468 52771 T281 T A Q E R N E T L F P A L I Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514754 455 50711 R283 L V E T A Q E R N E P I F P A
Chicken Gallus gallus Q4JIM4 468 52812 T282 T A Q E R N E T L F P A L I Y
Frog Xenopus laevis O12976 433 48282 L261 Y S S T M I W L V N M A D G D
Zebra Danio Brachydanio rerio Q9W6T7 456 50963 S278 I F P A L I Y S S T M V W L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02194 541 59286 Q303 T A Q E R N E Q I F P A L I Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52166 444 50016 E272 Y V L V T A V E N T T D P R E
Sea Urchin Strong. purpuratus XP_001178715 518 58077 Q314 T A Q E R D E Q I F P A L I Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O64668 453 49290 N278 N S H N M D Y N A I A V R D I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.7 82.2 46.2 N.A. 92.7 92.5 N.A. 62.3 82.2 77.3 70.8 N.A. 47.6 N.A. 49 55.6
Protein Similarity: 100 90.7 82.2 52 N.A. 96.5 96.5 N.A. 73.6 89.7 83 79 N.A. 63.4 N.A. 64 68.1
P-Site Identity: 100 6.6 6.6 13.3 N.A. 100 100 N.A. 13.3 100 6.6 0 N.A. 86.6 N.A. 0 80
P-Site Similarity: 100 13.3 20 20 N.A. 100 100 N.A. 20 100 20 20 N.A. 93.3 N.A. 0 93.3
Percent
Protein Identity: N.A. N.A. N.A. 20.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 43 0 8 8 8 0 0 8 0 15 65 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 15 0 0 0 0 0 8 8 8 15 % D
% Glu: 0 0 8 43 0 0 50 8 0 15 0 0 8 8 8 % E
% Phe: 0 8 0 0 0 0 0 0 0 43 0 0 8 0 8 % F
% Gly: 0 0 8 8 0 0 0 0 0 0 0 0 0 15 0 % G
% His: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 15 0 0 15 8 0 8 0 50 8 % I
% Lys: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 0 8 0 15 8 0 29 29 0 0 0 50 8 0 % L
% Met: 0 0 0 0 22 0 8 0 0 0 22 0 0 0 8 % M
% Asn: 8 0 0 8 0 36 0 8 15 15 0 0 0 0 0 % N
% Pro: 8 0 8 8 8 0 0 0 0 0 50 0 8 8 0 % P
% Gln: 0 0 43 0 0 8 0 15 8 8 0 0 8 0 0 % Q
% Arg: 0 0 0 0 43 8 0 8 0 0 0 0 8 8 8 % R
% Ser: 0 22 15 0 0 0 0 8 8 0 0 0 0 0 0 % S
% Thr: 43 0 0 22 8 0 0 29 0 15 15 0 0 0 0 % T
% Val: 0 15 0 8 0 8 15 0 22 0 0 15 0 0 0 % V
% Trp: 0 8 0 0 0 0 15 0 0 0 0 0 8 0 0 % W
% Tyr: 22 0 0 0 0 0 15 0 0 0 0 8 0 0 43 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _